Postdoctoral Fellow
National Institute of Mental Health
Section on Developmental Neurogenomics
brain evolution • sex differences
neurological conditions • normative neurodevelopment
comparative neuroanatomy • "omics"
Research
I am a biological anthropologist, evolutionary neuroscientist, & computational biologist.
In my work, I integrate these disciplines to ask and answer big questions that are central to our understanding of primate and, in particular, human brain evolution. These questions are wide in scope, and span both the proximate and ultimate mechanisms. For example:
- Which selective pressures led some primate species, including humans, to evolve relatively large brains?
- How and why do the brains of individuals of the same species differ (e.g., how are brains affected by age, sex, sociality, etc.)?
- What kinds of genetic, epigenetic, and transcriptomic changes led to these inter- and intra-specific differences?
- How do human brain sex differences contribute to sex-biases in the prevalence/presentation of certain neurological and psychiatric conditions?
I combine phylogenetic comparative methods, neuroimaging, ‘omics’, and bioinformatics to create a multidisciplinary approach that enables me to attack these types of questions with sophistication and rigor. This is the approach I took in my NSF-funded (GRFP, DDRIG) dissertation project – Variation in neuroanatomy and gene expression in primate brains. I am now at the NIMH working to characterize normative sex differences in brain cell-type specific gene expression patterns across the human brain.
I am thankful for every day spent learning something new. Leaving Wall Street was the best decision I've ever made.
Check out what my current lab and my PhD lab are up to!!
Ongoing projects
Characterizing normative sex differences in cell-type specific gene expression in the human brain
With Dr. Armin Raznahan
Linking the evolution of human gametologue expression to sex differences in disease
With Dr. Armin Raznahan
Evolutionary and biomedical implications of sex differences in the primate brain transcriptome
Click here to read the preprint!
DeCasien*, Chiou*, et al., In review
Primate microbiome effects on mouse brain gene expression
Ongoing collaboration with Dr. Katherine Amato's and Dr. Chris Kuzawa's Research Labs
Previous work
Research Articles
Links to disease and the social environment in the aging brain transcriptome
Chiou*, DeCasien*, et al. 2022
Click here to read the MS!
Greater variability inrhesus macaque (Macaca mulatta) endocranial volume among males
Colby*, DeCasien*, et al. 2022
Click here to read the MS!
Variation and heritability of retinal cone ratios in a free ranging population of rhesus macaques
Munds et al. 2022
Click here to read the MS!
Equivocal evidence for a link between megalencephaly-related genes and primate brain evolution
DeCasien et al. 2022
Click here to read the MS!
Social connections predict brain structure in a multidimensional free-ranging primate society
Testard et al. 2022
Click here to read the MS!
The expression of care: alloparental care frequency predicts neural control of facial muscles in primates
Cerrito & DeCasien 2021
Click here to read the MS!
Greater variability in chimpanzee (Pan troglodytes) brain structure among males
DeCasien et al. 2020
Click here to read the MS!
Relative cerebellum size Is not sexually dimorphic across primates
DeCasien & Higham 2020
Click here to read the MS!
Primate mosaic brain evolution reflects selection on sensory & cognitive specialization
DeCasien & Higham 2019
Click here to read the MS!
Social hierarchy position in female mice is associated w/ plasma cort & hypothalamic gene expression
Williamson et al. 2019
Click here to read the MS!
Encephalization & longevity coevolved in Euarchontoglires but not in other mammals
DeCasien et al. 2018
Click here to read the MS!
Primate brain size is predicted by diet, not sociality
DeCasien et al. 2017
Click here to read the MS, and here for a blog-style piece I wrote!
Media: Scientific American, NPR, New Scientist
Mentorship
Tiffany Ajumobi
NIH Academy Enrichment Program
Gabby Galindo +
Varvy Rousseau
NYU Diversity Undergraduate Research Incubator (DURI) Program
Zosia Caes +
Etta Harshaw
NYU Applied Research Innovations in Science and Engineering (ARISE) Program
Funding & Collaborations
Thank you to everyone who supports me and my research!
Natasha Kingsley © 2017